STATIN
Generic Name: Atorvastatin Tabs 10mg & 20mg
Packing: 1 x 10
Registration # 35607
Description:
STATIN (Atorvastatin) is a synthetic lipid-lowering agent. Atorvastatin is an inhibitor of 3-hydroxy3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis.
Chemically, Atorvastatin calcium is (R-(R*, R*))-2-(4-fluorophenyl-ß, & dihydroxy-5- (l-methylethyl)3-phenyl-4[(phenylamino) carbonyl]-1H-pyrrole-1 heptanoic acid, calcium salt (2:1) trihydrate.
Uses / Indications:
STATIN (Atorvastatin) is indicated:
- As an adjunct to diet to reduce elevated Total-C, LDL-C, Apolipoprotein B, and Triglycerides levels and to increase HDL-C in patients with primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Hyperlipoproteinaemias/Fredrickson Types lla and Ilb).
- As an adjunct to diet for the treatment of patients with elevated serum TG levels (Hypertriglyceridaemia/Fredrickson Type IV). For the treatment of patients with primary dysbetalipoproteinemia (Fredrickson Type III) who do not respond adequately to diet.
- To reduce Total-C and LDL-C in patients with homozygous familial hypercholesterolemia as an adjunct to diet and other non-pharmacological or lipid lowering treatments (e.g. LDL aphaeresis) or if such treatments are unavailable or inadequate.
- As an adjunct to diet to reduce Total-C, LDL-C, and Apolipoprotein B levels in children with heterozygous familial hypercholesterolemia, if after an adequate trial of diet therapy LDLC remains 190mg/dl or LDL-C remains 160mg/dl with positive family history of premature cardiovascular disease and/or two or more other CVD risk factors are present in the pediatric patient.
STATIN (Atorvastatin) is a synthetic lipid-lowering agent. Atorvastatin is an inhibitor of 3-hydroxy3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis.
Chemically, Atorvastatin calcium is (R-(R*, R*))-2-(4-fluorophenyl-ß, & dihydroxy-5- (l-methylethyl)3-phenyl-4[(phenylamino) carbonyl]-1H-pyrrole-1 heptanoic acid, calcium salt (2:1) trihydrate.
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